Resumo

VAZ, Nelissa Pacheco et al. Caavuranamide, a novel steroidal alkaloid from the ripe fruits of Solanum caavurana Vell. (Solanaceae). J. Braz. Chem. Soc. [online]. 2012, vol.23, n.2, pp. 361-366. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532012000200025.

Phytochemical investigation of the ripe fruits of Solanum caavurana Vell. (Solanaceae) afforded a novel steroidal alkaloid with spirosolane-type skeleton, named as caavuranamide, together with the alkaloids 4-tomatiden-3-one and 5α-tomatidan-3-one. Their structures were elucidated on the basis of spectroscopic methods. The antiproliferative and antimicrobial activities for the ethanolic extract, sub-fractions obtained from partition and acid-base treatment were also evaluated. Caavuranamide showed antibacterial activity similar to the chloramphenicol positive control against Rhodococcus equi.

Palavras-chave : Solanum caavurana; Solanaceae; caavuranamide; steroidal alkaloids; spirosolane.