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Bioactive phenylpropanoids from Daphne feddei

Investigation of acetone extract of the leaves and stems of Daphne feddei afforded three new phenylpropanoids, feddeiketones A-C (1-3), together with nine known phenylpropanoids (4-11). Their chemical structures were elucidated on the basis of spectroscopic methods. Compounds 1-3 were tested for their anti-HIV-1 activities and cytotoxicities against cancer cells. The results showed that compounds 1-3 have modest cytotoxic and anti-HIV-1 activities.

Daphne feddei; phenylpropanoids; feddeiketones A-C; anti-HIV-1 activity; cytotoxic activity


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