Journal of the Brazilian Chemical Society
Print version ISSN 0103-5053
SCHMIDT, Vanessa; BORSALI, Redouane and GIACOMELLI, Cristiano. Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups. J. Braz. Chem. Soc. [online]. 2012, vol.23, n.4, pp. 747-752. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532012000400021.
Surface engineering for precise positioning of biomolecules is of particular interest for controlled fabrication of biochips. In this study, a novel approach for the preparation of nanodomains with phosphonic diacid groups that were previously shown to reversibly bind to a family of proteins (annexins) in a calcium-dependent manner is described. The strategy makes use of polystyrene-b-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA) precursors prepared by atom transfer radical polymerization (ATRP) to obtain hexagonally packed PS cylinders (fPS = 0.25-0.27) in a PHEMA matrix. The pendant hydroxyl groups of PHEMA are then partially (ca. 20%) converted into phosphonic diacid groups via sequential reactions involving phosphorylation, silylation and methanolysis. This process produces PS-b-P(HEMA-co-PEMA) derivatives that still retain the hexagonal morphology, but their degree of structural organization is reduced comparatively to the precursors.
Keywords : block copolymers; self-assembly; nanostructures.