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Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053

Abstract

D. NETO, Brenno A. et al. Selective and efficient mitochondrial staining with designed 2,1,3-benzothiadiazole derivatives as live cell fluorescence imaging probes. J. Braz. Chem. Soc. [online]. 2012, vol.23, n.4, pp. 770-781. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532012000400024.

Novel designed 2,1,3-benzothiadiazole fluorescent probes were synthesized, characterized and applied as live cell fluorescence imaging probe staining only mitochondria in mammalian cancer cell lines (MCF-7). The efficiency of these new probes was found to be much superior to that of the commercially available MitoTracker® Red. Cellular and in vitro experiments allowed better understanding of the relationship between the planned molecular architecture of the new dyes and the observed cellular selectivity.

Keywords : benzothiadiazole; synthesis; mitochondria; cellular staining.

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