SciELO - Scientific Electronic Library Online

 
vol.23 issue7New flavonoids and coumarins from Platymiscium floribundum VogelSolvent extraction studies on uranium using amine based extractants and recovery from low grade ore leach liquors author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053

Abstract

SERVAT, Leila et al. Pterodon pubescens benth: stability study of microencapsulated extract and isolated compounds monitored by antinociceptive assays. J. Braz. Chem. Soc. [online]. 2012, vol.23, n.7, pp. 1244-1253. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532012000700008.

Pterodon pubescens Benth. (Pp) seeds, commercially available in Brazil, are used in folk medicine in anti-inflammatory, analgesic, and anti-rheumatic preparations. The present study demonstrated the antinociceptive properties of isomers 6α-hydroxy-7β-acetoxy-vouacapan-17β-oate methyl ester and 6α-acetoxy-7β-hydroxy-vouacapan-17β-oate methyl ester (C1), isolated from (Pp), employing different experimental models. A stability study was performed to investigate the relationship of microencapsulation by spray-drying on the maintenance of antinociceptive action. Therefore, C1 and Pp extract samples were monitored in accelerated stability study, evaluating both microencapsulated and non-microencapsulated samples. It was observed that sample C1 possess antinociceptive activity revealed by writhing and formalin tests; C1 showed significantly anti-allodynic, but not antihyperalgesic effect; the microencapsulation maintained the activity and integrity of both, sample C1 and Pp crude extract; microencapsulation by spray drying is a useful alternative to increase shelf life.

Keywords : microcapsules; stability; spray-drying; antinociceptive; Pterodon pubescens.

        · abstract in Portuguese     · text in English     · pdf in English