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Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053


SERVAT, Leila et al. Pterodon pubescens benth: stability study of microencapsulated extract and isolated compounds monitored by antinociceptive assays. J. Braz. Chem. Soc. [online]. 2012, vol.23, n.7, pp. 1244-1253. ISSN 0103-5053.

Pterodon pubescens Benth. (Pp) seeds, commercially available in Brazil, are used in folk medicine in anti-inflammatory, analgesic, and anti-rheumatic preparations. The present study demonstrated the antinociceptive properties of isomers 6α-hydroxy-7β-acetoxy-vouacapan-17β-oate methyl ester and 6α-acetoxy-7β-hydroxy-vouacapan-17β-oate methyl ester (C1), isolated from (Pp), employing different experimental models. A stability study was performed to investigate the relationship of microencapsulation by spray-drying on the maintenance of antinociceptive action. Therefore, C1 and Pp extract samples were monitored in accelerated stability study, evaluating both microencapsulated and non-microencapsulated samples. It was observed that sample C1 possess antinociceptive activity revealed by writhing and formalin tests; C1 showed significantly anti-allodynic, but not antihyperalgesic effect; the microencapsulation maintained the activity and integrity of both, sample C1 and Pp crude extract; microencapsulation by spray drying is a useful alternative to increase shelf life.

Keywords : microcapsules; stability; spray-drying; antinociceptive; Pterodon pubescens.

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