Journal of the Brazilian Chemical Society
Print version ISSN 0103-5053
VALE, Juliana A. et al. Lanthanide nitrates as Lewis acids in the one-pot synthesis of 1,2,4-oxadiazole derivatives. J. Braz. Chem. Soc. [online]. 2012, vol.23, n.8, pp.1437-1440. Epub July 31, 2012. ISSN 0103-5053. http://dx.doi.org/10.1590/S0103-50532012005000002.
In this work we report the use of lanthanide nitrates [Ln(NO3)3] acting as catalyst in direct one-pot synthesis of 3-benzoyl- and 3-acetyl-1,2,4-oxadiazoles derivatives from ketones, nitriles and nitric acid. This is the first example of one-pot synthesis of benzoyl- and acetyl 1,2,4-oxadiazoles derivatives preparation using acetophenones derivates with electron-donator groups.
Keywords : lanthanide nitrates; Lewis acids; 1,2,4-oxadiazole derivates.