SciELO - Scientific Electronic Library Online

 
vol.23 issue8Evaluation of herbicidal potential of depsides from Cladosporium uredinicola, an endophytic fungus found in Guava fruitPhotocatalytic degradation of camphor by suspended and immobilized photocatalysts author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Journal of the Brazilian Chemical Society

Print version ISSN 0103-5053

Abstract

FREITAS, Hozana Patrícia S. et al. Cytotoxic cordiaquinones from the roots of Cordia polycephala. J. Braz. Chem. Soc. [online]. 2012, vol.23, n.8, pp. 1558-1562.  Epub Aug 16, 2012. ISSN 0103-5053.  http://dx.doi.org/10.1590/S0103-50532012005000019.

The chemical investigation of roots of Cordia polycephala resulted in the isolation of two new terpenoid naphtoquinones, 6-[10-(12,12-dimethyl-13α-(22-methyl-21-butenoyloxy)-16-methenylcyclohexyl)ethyl]-naphtalene-1,4-dione and (6-[10-(12,12-dimethyl-13α-(tigloyloxy)-16-methenylcyclohexyl)ethyl]-naphtalene-1,4-dione, named as cordiaquinone N (1) and O (2), respectively. The known cordiaquinones B (3), L (4) and E (5) were also isolated. Their structures were elucidated after detailed 1D and 2D NMR and high resolution electrospray ionization mass spectrometry (HRESIMS) data analysis. All cordiaquinones (1-5) were evaluated against four human cancer cell lines: HCT-8 (colon), HL-60 (leukemia), MDA-MB-435 (melanoma) and SF295 (glioblastoma), showing IC50 values in the range of 1.2 to 11.1 mmol L-1. The new cordiaquinones 1 and 2 were the most active against all cancer cell lines, while compound 3 was selective to leukemia HL-60 cells (IC50 2.2 mmol L-1).

Keywords : Cordia polycephala; cordiaquinones; cytotoxic activity.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License