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Electrocatalytic detection of glutathione - the search for new mediators

We report the possibility to use different mediators such as acetaminophen, 4-aminophenol, 4-amino-2,6-dichlorophenol and 4-amino-2,6-diphenylphenol to detect glutathione using a nanocarbon paste electrode. The detection is based on the electrocatalytic response involving the electrochemically generated quinoneimines and glutathione. 4-aminophenol is recommended as the most sensitive mediator in terms of giving the lowest limit detection of 0.80 µmol L-1.

nanocarbon paste electrode; acetaminophen; 4-aminophenol; 4-amino-2,6-dichlorophenol; 4-amino-2,6-diphenylphenol; glutathione


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