This work aimed to develop and validate a routine method for the specific determination of Sn2+ 2-methoxy isobutyl isonitrile (MIBI) radiopharmaceutical kits. A voltammetric electrochemical technique was used for the analysis. Screening experiments revealed that 1 mol L-1 HCl electrolyte showed the best results, among all the tested solutions. Stability experiments showed a gradual decline in the current of MIBI, and 23 days after the preparation of the solution, the current corresponding to stannous ion disappeared. To confirm the selectivity of the technique using HCl, we have induced oxidation of SnCl2 that resulted in a proportional decline of the current in the voltammogram. The reliability of the method was observed with the values of precision and accuracy intra- and inter-assay, and also its robustness. We provide novel evidence on the selective detection of Sn2+ in the presence of its oxidized form in radiopharmaceutical kits, by using 1 mol L-1 HCl as electrolyte.
stannous ion; radiopharmaceutical kits; selective electroanalysis; electrolyte; voltammetry
