|
|
|
Estratégia protetora
|
|
Grupo controle
|
|
|
|
Brochard et al.(77 Brochard L, Roudot-Thoraval F, Roupie E, Delclaux C, Chastre J, Fernandez-Mondejar E, et al. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am J Respir Crit Care Med. 1998;158(6):1831-8.)
|
1998 |
108 |
7,1 |
25,7 |
10,7 |
15 |
46,6 |
10,3 |
31,7 |
10,7 |
21 |
37,9 |
6 |
ns |
Stewart et al.(88 Stewart TE, Meade MO, Cook DJ, Granton JT, Hodder RV, Lapinsky SE, et al. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med. 1998;338(6):355-61.)
|
1998 |
120 |
7,2 |
22,3 |
8,6 |
13,7 |
48,0 |
10,8 |
26,8 |
7,2 |
19,6 |
46,0 |
5,9 |
ns |
Ranieri et al.(55 Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1999;282(1):54-61.)
|
1999 |
44 |
7,6 |
24,6 |
14,8
|
9,8 |
38,0 |
11,1 |
31 |
6,5 |
24,5 |
58,0 |
14,7 |
0,19 |
Brower et al.(99 Brower RG, Shanholtz CB, Fessler HE, Shade DM, White P Jr, Wiener CM, et al. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med. 1999;27(8):1492-8.)
|
1999 |
52 |
7,3 |
27 |
9,3 |
17,7 |
50,0 |
10,2 |
30 |
8,2 |
21,8 |
46,0 |
4,1 |
ns |
Amato et al.(44 Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 1998;338(6):347-54.)
|
1998 |
53 |
6 |
31,8 |
16,3
|
15,5 |
38,0 |
12 |
34,4 |
6,9 |
27,5 |
71,0 |
12 |
< 0,001 |
ARDSnet(22 Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301-8.)
|
2000 |
861 |
6,1 |
25 |
9,4 |
15,6 |
31,0 |
11,9 |
33 |
8,6 |
24,4 |
39,8 |
8,8 |
0,007 |
|
|
|
PEEP alta
|
|
PEEP baixa
|
|
|
|
ALVEOLI(1010 Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004;351(4):327-36.)
|
2004 |
549 |
6,1 |
27 |
14,7 |
12,3 |
27,5 |
6,0 |
24 |
9,1 |
14,9 |
24,9 |
2,6 |
ns |
Mercat et al.(1212 Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L; Expiratory Pressure (Express) Study Group. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299(6):646-55.)
|
2008 |
767 |
6,1 |
27,5 |
15,8 |
11,7 |
35,4 |
6,1 |
21,1 |
8,4 |
12,7 |
39,0 |
1,0 |
ns |
Meade et al.(1111 Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE; Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299(6):637-45.)
|
2008 |
983 |
6,8 |
30,2 |
15,6 |
14,6 |
36,4 |
6,8 |
24,9 |
10,1 |
14,8 |
40,4 |
0,2 |
ns |
Kacmarek et al.(1515 Kacmarek RM, Villar J, Sulemanji D, Montiel R, Ferrando C, Blanco J, Koh Y, Soler JA, Martinez D, Hernández M, Tucci M, Borges JB, Lubillo S, Santos A, Araujo JB, Amato MB, Suárez-Sipmann F; Open Lung Approach Network. Open Lung Approach for the Acute Respiratory Distress Syndrome: A Pilot, Randomized Controlled Trial. Crit Care Med. 2016;44(1):32-42.)
|
2016 |
200 |
5,6 |
27,9 |
15,8 |
11,8 |
22 |
6,2 |
25,2 |
11,6 |
13,8 |
27 |
2,0 |
0,18 |
|
|
|
Ventilação protetora convencional
|
|
VOAF
|
|
|
|
Young et al.(3131 Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH; OSCAR Study Group. High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med. 2013;368(9):806-13.)
|
2013 |
795 |
8,3 |
30,9 |
11,4 |
19,5 |
41,1 |
- |
- |
- |
- |
41,7 |
- |
ns |
Ferguson et al.(3232 Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med. 2013;368(9):795-805.)
|
2013 |
548 |
6,4 |
29,0 |
15,0 |
14,0 |
35,0 |
- |
- |
- |
- |
47,0 |
- |
0,005 |