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Fisioterapia em Movimento

versão impressa ISSN 0103-5150versão On-line ISSN 1980-5918

Resumo

PIEREZAN, Bruna et al. Oxidative profile of patients with osteoarthrosis undergoing total knee arthroplasty. Fisioter. mov. [online]. 2014, vol.27, n.2, pp.165-171. ISSN 0103-5150.  http://dx.doi.org/10.1590/0103-5150.027.002.AO01.

Introduction

Total knee arthroplasty may be the most appropriate method of treatment in several cases of osteoarthritis. This disease causes tissue damage, which is closely related to the production of free radicals, leading to oxidative stress and to lipid damage. Because of that, the body has several antioxidative defense systems involved in detoxification (antioxidants).

Objective

Based on the previous information, the goal of this study was to establish the systemic and local oxidative profile of individuals with osteoarthritis submitted to total knee arthroplasty.

Materials and methods

The sample consisted of four female patients (65.5 ± 0.7 years) with osteoarthritis of the knee. Blood and synovial fluid (SF) samples were collected from the patients 15 minutes before surgery. The concentrations of flavonoids, catalase, and TBARS were then quantified.

Results

The results indicate a higher catalase activity in the SF than in the serum (S), (SF = 1 S = 14.3 ± 3.1 ± 0.8). The concentration of TBARS proved to be higher in the SF (SF = 0.29 ± 0.02 S = 0.09 ± 0.05), whereas the concentration of phenols was higher in the serum (SF = 3.2 S = 5.2 ± 0.2 ± 0.6).

Conclusion

Osteoarthritis is a disease that increases the oxidative stress markers in the serum and in the SF.

Palavras-chave : Osteoarthritis; Knee; Oxidative stress; Antioxidants; Free radicals.

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