SciELO - Scientific Electronic Library Online

vol.23 issue21-Year clinical study of indirect resin composite restorations luted with a self-adhesive resin cement: effect of enamel etching author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Brazilian Dental Journal

Print version ISSN 0103-6440


AMARAL, Fabrício Rezende et al. Cell proliferation and apoptosis in ameloblastomas and keratocystic odontogenic tumors. Braz. Dent. J. [online]. 2012, vol.23, n.2, pp.91-96. ISSN 0103-6440.

A high proliferative activity of the odontogenic epithelium in ameloblastoma (AM) and keratocystic odontogenic tumor (KOT) has been demonstrated. However, no previous study has simultaneously evaluated cell proliferation and apoptotic indexes in AM and KOT, comparing both lesions. The aim of this study was to assess and compare cell proliferation and apoptotic rates between these two tumors. Specimens of 11 solid AM and 11 sporadic KOT were evaluated. The proliferation index (PI) was assessed by immunohistochemical detection of Ki-67 and the apoptotic index (AI) by methyl green-pyronine and in situ DNA nick end-labelling methods. KOT presented a higher PI than AM (p<0.05). No statistically significant difference was found in the AI between AM and KOT. PI and AI were higher in the peripheral cells of AM and respectively in the suprabasal and superficial layers of KOT. In conclusion, KOT showed a higher cell proliferation than AM and the AI was similar between these tumors. These findings reinforce the classification of KOT as an odontogenic tumor and should contribute to its aggressive clinical behavior.

Keywords : cell proliferation; apoptosis; ameloblastoma; odontogenic keratocyst.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License