2003 |
Schmelzeisen et al. 6565 Schmelzeisen R, Schimming R, Sittinger M, et al. Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report. J Craniomaxillofac Surg 2003;31:34-39.
|
Periosteal |
Polymer fleece |
|
2 |
4 months |
Histologic and clinical |
Mineralized tissue formed |
2004 |
Warnke et al. 7777 Warnke PH, Springer IN, Wiltfang J, Acil Y, Eufinger H, Wehmoller M, et al . Growth and transplantation of a custom vascularised bone graft in a man. Lancet2004;364:766-770.
|
BMAC |
BioOss |
rhBMP7 |
1 |
|
Clinical and radiographic |
Mineralized tissue formed |
2005 |
Ueda et al. 3939 Ueda M, Yamada Y, Ozawa R, et al. Clinical case reports of injectable tissue-engineered bone for alveolar augmentation with simultaneous implant placement. Int J Periodontics Restorative Dent 2005;25:129-137.
|
BMMSC |
PRP-b-TCP injectable |
|
6 |
12 months |
Radiographic |
Mineralized tissue formed (7.3 ± 4.6 mm) |
2007 |
Cerruti et al. 7575 Filho-Cerruti H, Kerkis I, Kerkis A, Tatsui NH, da Costa Neves A, Bueno DF, et al . Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: clinical case reports. Artif Organs2007;31:268-273.
|
MNC |
PRP and Bone scaffod |
|
32 |
8 months |
CT, histologic and clinical |
Mineralized tissue formed |
2007 |
Soltan et al. 7878 Soltan M, Smiler D, Prasad HS, Rohrer MD, et al. Bone block allograft impregnated with bone marrow aspirate. Implant Dent 2007;16:329-339.
|
BMAC |
Allograft bone block |
|
5 |
8 months |
Histologic and histomorphometry |
Mineralized tissue formed (54%) |
2007 |
Smiler et al. 7979 Smiler D, Soltan M, Lee JW, et al . A histomorphogenic analysis of bone grafts augmented with adult stem cells. Implant Dent 2007;16:42-53.
|
BMAC |
PepGen Putty or C-Graft |
|
5 |
7 months |
Clinical and histologic |
Mineralized tissue formed; (45%) |
2007 |
Zizelmann et al. 7171 Zizelmann C, Schoen R, Metzger MC, Schmelzeisen R, Schramm A, Dott B, et al . Bone formation after sinus augmentation with engineered bone. Clin Oral Implants Res 2007;18:69-73.
|
Osteoblast |
PLGA |
|
10 |
3 months |
CT |
Mineralized tissue formed; High resorption of scaffolds |
2008 |
Pradel et al. 7272 Pradel W, Mai R, Hagedorn GM, Lauer G, Allegrini S, et al . The biomaterial influences the ossification after sinus floor elevation using tissue-engineered bone grafts. Biomedizinische Technik 2008;53:224-228.
|
Osteoblast |
Demineralized bovine bone matrix or from solvent-dehydrated mineralized bovine bone; and graft |
|
6 |
1 year |
Histologic |
Mineralized tissue formed. Inflammation and some scaffold resorption was found in 5 months |
2008 |
Shayesteh et al. 4040 Shayesteh YS, Khojasteh A, Soleimani M, Alikhasi M, Khoshzaban A, Ahmadbeigi N, et al. Sinus augmentation using human mesenchymal stem cells loaded into a beta-tricalcium phosphate/hydroxyapatite scaffold. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:203-209.
|
BMMSC |
b-TCP/hydroxyapatite |
|
6 |
12 months |
Clinical, radiographic and histologic |
Mineralized tissue formed (41.3%) |
2008 |
Yamada et al. 4141 Yamada Y, Nakamura S, Ito K, Kohgo T, Hibi H, Nagasaka T, et al . Injectable tissue-engineered bone using autogenous bone marrow-derived stromal cells for maxillary sinus augmentation: clinical application report from a 2-6-year follow-up. Tissue Eng Part A 2008;14:1699-1707.
|
BMMSC |
PRP Injectable |
|
12 |
2-6.3 years: 6.3/ 6.3/ 5.3/ 4.9/ 4.3/ 4.3/ 3.3/ 3.5/ 3.0/ 3.3/ 2.1/ 2.1/ 3.8/ 2.5/ 2.5/ 2.0 |
Orthopantomograms, histologic, CT |
Mineralized tissue formed; increases of 8.8 ± 1.6 mm |
2009 |
Behnia et al. 6262 Behnia H, Khojasteh A, Soleimani M, Tehranchi A, Khoshzaban A, Keshel SH, et al . Secondary repair of alveolar clefts using human mesenchymal stem cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:e1-6.
|
MSC |
Demineralized bone mineral and calcium sulfate (Osteoset) |
|
2 |
4 months |
CT |
Mineralized tissue formed (34.5%) |
2009 |
D’Aquino et al. 5858 d’Aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, et al. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
|
DPSC |
Collagen sponge |
|
7 |
3 months |
Histologic and radiographic |
Mineralized tissue formed |
2009 |
Mangano et al. 7373 Mangano C , Piattelli A , Mangano A , Mangano F , Mangano A , Iezzi G, et al Combining scaffolds and osteogenic cells in regenerative bone surgery: a preliminary histological report in human maxillary sinus augmentation. Clin Implant Dent Relat Res 2009:11;e92-1e02.
|
Osteoblasts |
PLGA |
|
5 |
6 months |
Clinical, histologic and CT |
Mineralized tissue formed; fast resorption of scaffold |
2009 |
McAllister et al. 7070 McAllister BS, Haghighat K, Gonshor A, et al. Histologic Evaluation of a Stem Cell-Based Sinus-Augmentation Procedure. J Periodontol 2009;80:679-686.
|
MSC and osteoprogenitor cells |
Bone graft |
|
5 |
4.1 months |
Clinical, radiographic and histologic |
Mineralized tissue formed; (vital bone content of 33% - 22% to 40%-) |
2010 |
Lee et al. 4242 Lee J, Sung HM, Jang JD, Park YW, Min SK, Kim EC, et al. Successful reconstruction of 15-cm segmental defects by bone marrow stem cells and resected autogenous bone graft in central hemangioma. J Oral Maxillofac Surg 2010;68:188-194.
|
BMMSC |
Freeze-dried autobone tray and fibrin glue |
|
1 |
7 months |
Histological, clinical and radiographic |
Mineralized tissue formed |
2010 |
Sauerbier et al. 4343 Sauerbier S, Stricker A, Kuschnierz J, Buhler F, Oshima T, Xavier SP, et al. In vivo comparison of hard tissue regeneration with human mesenchymal stem cells processed with either the FICOLL method or the BMAC method. Tissue Eng Part C Methods 2010;16:215-223.
|
BMMSC |
FICOLL |
|
4 |
4,1 months; clinical 2 years |
Histologic and clinical |
Mineralized tissue formed (19.9% Confidence interval 945% 10.9 to 29%) |
2010 |
Soltan et al. 8080 Soltan M, Smiler D, Soltan C, Prasad HS, Rohrer MD, et al. Bone grafting by means of a tunnel dissection: predictable results using stem cells and matrix. Implant Dent 2010;19:280-287.
|
BMMAC |
Resorbable hydroxylapatite OR Allograft |
|
2 |
4-6 months |
Histologic and radiographic |
Mineralized tissue formed (34% to 45%) |
2010 |
Mangano et al. 6969 Mangano C, Piattelli A, Tettamanti L, Mangano F, Mangano A, Borges F, et al . Engineered bone by autologous osteoblasts on polymeric scaffolds in maxillary sinus augmentation: histologic report. J Oral Implantol2010;36:491-496.
|
Osteoblasts |
PLGA |
|
1 |
6 months |
Histologic and CT |
Mineralized tissue formed (28.89% bone and 71.11% medullary spaces) |
2011 |
Brunelli et al. 5959 Brunelli G, Motroni A, Carinci F, Graziano A, D’aquino R, Zollino I, et al. Sinus lift augmentation using autologous pulp stem cells: Case report of bone density evaluation. J Inflamm (Lond) 2011;9:31-35.
|
DPSC |
Collagen sponge |
|
1 |
4 months |
Clinical, radiographic and histologic |
Mineralized tissue formed |
2011 |
Graziano et al. 3636 Graziano A, D’aquino R, Brunelli G, Fanali S, Carinci F, et al. Sinus lift augmentation using pulp stem cells: A case report and histological evaluation. J Inflamm (Lond) 2011;9.
|
DPSC |
Collagen sponge |
|
1 |
6 months |
Clinical and radiographic |
Mineralized tissue formed |
2011 |
Montesani et al. 6868 Montesani L, Schulze-Spate U, Dibart S, et al. Sinus augmentation in two patients with severe posterior maxillary height atrophy using tissue-engineered bone derived from autologous bone cells: a case report. Int J Periodontics Restorative Dent 2011;31:391-399.
|
osteoblast and periosteal cells |
nonwoven polyglactin-910 fibers connected by poly-p-dioxanon bonding |
|
2 |
12 months |
Clinical and radiographic |
Mineralized tissue formed |
2011 |
Rickert et al. 4949 Rickert D, Sauerbier S, Nagursky H, Menne D, Vissink A, Raghoebar GM, et al. Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial. Clin Oral Implants Res 2011;22:251-258.
|
BMMSC |
BioOsss and autogenous stem cells (Test); BioOsss mixed with autogenous bone (Control) |
|
12 |
14.8 weeks 3-4 months |
Histologic |
Mineralized tissue formed; test group presented more bone formation than control |
2011 |
Sauerbier et al. 8181 Sauerbier S, Rickert D, Gutwald R, Nagursky H, Oshima T, Xavier SP, et al . Bone marrow concentrate and bovine bone mineral for sinus floor augmentation: a controlled, randomized, single-blinded clinical and histological trial-per-protocol analysis. Tissue Eng Part A 2011;17:2187-2197.
|
BMAS |
Autogenous bone combination with a bovine bone mineral |
|
26 |
biopsies 3-4 month |
Histologic |
Mineralized tissue formed (12.6% ± 1.7%) |
2011 |
Schmelzeisen et al. 8282 Schmelzeisen R, Gutwald R, Oshima T, Nagursky H, Vogeler M, Sauerbier S, et al Making bone II: maxillary sinus augmentation with mononuclear cells-case report with a new clinical method. British Journal of Oral & Maxillofacial Surgery 2011;49:480-482.
|
BMAC |
FICOLL |
|
1 |
3 months |
Histologic |
Mineralized tissue formed (26.9%); no signs of inflammation |
2012 |
Behnia et al. 6363 Behnia H, Khojasteh A, Soleimani M, Tehranchi A, Atashi A, et al . Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: a preliminary report. J Craniomaxillofac Surg 2012;40:2-7.
|
MSC |
Synthetic biphasic bone substitute |
PDGF |
3 |
3 months |
CT |
Mineralized tissue formed (51.3%) |
2012 |
Hernández-Alfaro et al. 8383 Hernandez-Alfaro F, Ruiz-Magaz V, Chatakun P, Guijarro-Martinez R, et al. Mandibular reconstruction with tissue engineering in multiple recurrent ameloblastoma. Int J Periodontics Restorative Dent 2012;32:e82-e86.
|
BMAC |
Bovine HA |
rhBMP-7 |
1 |
1 year |
Histologic, clinical and radiographic |
Mineralized tissue formed |
2012 |
Soltan et al. 7474 Soltan M, Rohrer MD, Prasad HS. Monocytes: super cells for bone regeneration. Implant Dent 2012;21:13-20.
|
Concentrated of monocytes |
Demineralized allograft material |
|
2 |
1 year |
Radiographic and histologic |
Mineralized tissue formed |
2012 |
Nagata et al. 6767 Nagata M, Hoshina H, Li M, Arasawa M, Uematsu K, Ogawa S, et al. A clinical study of alveolar bone tissue engineering with cultured autogenous periosteal cells: coordinated activation of bone formation and resorption. Bone2012;50:1123-1129.
|
Periosteal |
Autogenous bone and PRP |
|
25 |
1 year |
CT |
Mineralized tissue formed |
2013 |
Giuliani et al. 66 Giuliani A, Manescu A, Langer M, Rustichelli F, Desiderio V, Paino F, et al. Three years after transplants in human mandibles, histological and in-line holotomography revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implications. Stem Cells Transl Med 2013;2:316-324.
|
DPSC |
Collagen sponge |
|
7 |
3 years |
Histologic and radiographic |
Mineralized tissue formed |
2013 |
Kaigler et al. 4444 Kaigler D, Pagni G, Park CH, Braun TM, Holman LA, Yi E, et al. Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. Cell transplantat 2013;22:767-777.
|
BMMSC |
Absorbable gelatin sponge |
|
N=12 Control=12 |
1 year |
Clinical, radiographic, CT and histologic |
Mineralized tissue formed; therapy accelerated alveolar bone regeneration |
2013 |
Sandor et al. 5757 Sandor GK, Tuovinen VJ, Wolff J, Patrikoski M, Jokinen J, Nieminen E, et al. Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration. J Oral Maxillofac Surg2013;71:938-950.
|
ASC |
b-TCP |
rhBMP-2 |
1 |
10 months |
Histological |
Mineralized tissue formed |
2013 |
Yamada et al. 4646 Yamada Y, Hara K, Nakamura S, Ueda M, Ito K, Nagasaka T, et al. Minimally invasive approach with tissue engineering for severe alveolar bone atrophy case. Int J Oral Maxillofac Surg 2013;42:260-263.
|
BMMSC |
Membran + PRP Injetável |
|
1 |
24 months |
Histological, CT and radiographic |
Mineralized tissue formed |
2013 |
Yamada et al. 4545 Yamada Y, Nakamura S, Ito K, Umemura E, Hara K, Nagasaka T, et al. . Injectable bone tissue engineering using expanded mesenchymal stem cells. Stem Cells 2013;31:572-580.
|
BMMSC |
PRP Injectable |
|
|
3 months |
Clinical |
Mineralized tissue formed.; all patients improved bone tissue |
2013 |
Zamiri et al. 4747 Zamiri B, Shahidi S, Eslaminejad MB, Khoshzaban A, Gholami M, Bahramnejad E, et al . Reconstruction of human mandibular continuity defects with allogenic scaffold and autologous marrow mesenchymal stem cells. J Craniofac Surg2013;24:1292-1297.
|
BMMSC |
Bone Human cadavers (allograft) |
|
3 |
6 months |
CT |
Mineralized tissue formed |
2014 |
Marx et al. 8484 Marx RE, Harrell DB, et al . Translational research: The CD34+ cell is crucial for large-volume bone regeneration from the milieu of bone marrow progenitor cells in craniomandibular reconstruction. Int J Oral Maxillofac Implants 2014;29:e201-e209.
|
BMAC |
Collagen sponge |
rhBMP-2 |
40 |
6 months |
Clinical, CT, radiographic and histologic |
Mineralized tissue formed; Patients that received cells presented more bone formation |
2014 |
Rajan et al. 4848 Rajan A, Eubanks E, Edwards S, Aronovich S, Travan S, Rudek I, et al. Optimized cell survival and seeding efficiency for craniofacial tissue engineering using clinical stem cell therapy. Stem Cells Transl Med 2014;3:1495-1503.
|
BMMSC |
b-TCP |
|
1 |
biopsy 4 months; and 6 months follow-up |
CT and histologic |
Mineralized tissue formed; 80% of the original jawbone |
2014 |
Rickert et al. 5050 Rickert D, Vissink A, Slot WJ, Sauerbier S, Meijer HJ, Raghoebar GM, et al. Maxillary sinus floor elevation surgery with BioOss(R) mixed with a bone marrow concentrate or autogenous bone: test of principle on implant survival and clinical performance. Int J Oral Maxillofac Surg 2014;43:243-247.
|
BMMSC |
BioOss + MSCs and BioOss + autogenous bone |
|
12 |
1 year |
Clinical and radiographic |
Mineralized tissue formed; 3 implant (91%) failed in osteointegration |
2014 |
Wildburger et al. 5151 Wildburger A, Payer M, Jakse N, Strunk D, Etchard-Liechtenstein N, Sauerbier S, et al . Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone substitute - a split-mouth pilot study. Clin Oral Implants Res 2014;25:1175-1181.
|
BMMSC |
Bio-Oss |
|
7 |
3 and 6 months |
Histological and CT |
Mineralized tissue formed (13.5%) |
2015 |
Bertolai et al. 5252 Bertolai R, Catelani C, Aversa A, Rossi A, Giannini D, Bani D, et al. Bone graft and mesenchimal stem cells: clinical observations and histological analysis. Clin Cases Miner Bone Metab 2015;12:183-187.
|
BMMSC |
PRP and corticocancellous freeze-dried bone chips |
|
20 |
3 months |
Histological and clinical |
Mineralized tissue formed |
2015 |
Park et al. 5353 Park JS, Kim BC, Kim BH, Lee JI, Lee J, et al. Up-and-coming mandibular reconstruction technique with autologous human bone marrow stem cells and iliac bone graft in patients with large bony defect. J Craniofac Surg 2015;26:e718-e720.
|
BMMSC |
Bone from the iliac crest; collagenous membrane |
|
1 |
1 year |
Clinical and radiographic |
Mineralized tissue formed |
2015 |
Kaigler et al. 5454 Kaigler D, Avila-Ortiz G, Travan S, Taut AD, Padial-Molina M, Rudek I, et al . Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial. J Bone Miner Res 2015;30:1206-1216.
|
BMMSC |
b-TCP |
|
Test=13; Control=13 |
1 year |
Clinical, radiographic, and histologic |
Mineralized tissue formed (12.2% ±3.3) |
2015 |
Pasquali et al. 8585 Pasquali PJ, Teixeira ML, de Oliveira TA, de Macedo LGS, Aloise AC, Pelegrine AA, et al . Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans. Int J Biomater 2015: 121286.
|
BMAC |
Bio-Oss |
|
8 |
6 months |
Histologic |
Mineralized tissue formed (55.15 ± 20.91) |