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On-line version ISSN 1678-4596
LEMOS, Ricardo Antonio Amaral de et al. Photosensitization and crystal associated cholangiopathy in sheep grazing Brachiaria decumbens. Cienc. Rural [online]. 1996, vol.26, n.1, pp.109-113. ISSN 1678-4596. http://dx.doi.org/10.1590/S0103-84781996000100020.
Two outbreaks of photosensitization were observed in sheep grazing Brachiaria decumbens in the state of Mato Grosso do Sul, Central Brazil. Clinical signs included swelling and dermatitis of the face, ears and eyelids, conjuntivitis. ocular discharge, blindness, and increased serum levels of AST e GT. Some sheep recoveredand others died within 3-7 days. The livers were sligthy enlarged and firm with white-yellowish or brown-yellowish discoloration. The bile ducts and gall bladder were sligthly enlarged. The main histological changes were the presence of optically active birefringent crystals in the bile ducts and within hepatocytes of periportal áreas. Necrosis of the bile duct epithelium, periportal fibrosis with infiltration of inflammatory cells and bile duct proliferation were also observed. Groups of large cells with excentric nuclei and foamy eosinofilic cytoplasm werepresent in the periportal and centrilobular áreas. Numerous groups of such cells were also observed in the cortex and medulla of the hepatic lymph nodes. No couhtable amounts of spores of Pithomyces chartarum were observed in the samples from the pasture where the seep grazed; from 30 cultures isolated from these samples, only one produced sporidesmin. It is concluded that the toxicosis was due the ingestion of Brachiaria decumbens.
Keywords : hepatotoxicosis; Brachiaria decumbens; sheep diseases.