SciELO - Scientific Electronic Library Online

vol.34 issue1Radiographic aspects of chronic valvular diseaseEffects of topical 2% cyclosporine A on the corneas of dogs subjected to lamellar keratoplasty with a graft of equine pericardium preserved in glycerin: clinical and morphological evaluation author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Ciência Rural

On-line version ISSN 1678-4596


NUNES, Newton; REZENDE, Márlis Langenegger de; SANTOS, Paulo Sérgio Patto dos  and  WANG, Lilia. Sevoflurane and desflurane in cardiac rhythm of dogs treated with increasing doses of epinephrine. Cienc. Rural [online]. 2004, vol.34, n.1, pp.125-130. ISSN 1678-4596.

The volatile anesthetics increase the sensibility of the myocardium or its conduction system to the action of endogenous and/or exogenous epinephrine, predisposing the animal to cardiac arrhythmias. Among the volatile anesthetics, sevoflurane and desflurane are quite recent drugs and even though they have antiarrhythmogenic characteristics, there aren’t studies comparing these properties. The aim of this work was to study comparatively the cardiac rhythm and observe occasional atrioventricular blockages in dogs anesthetized with desflurane and sevoflurane, receiving increasing doses of epinephrine. 20 healthy adult male and female mongrel dogs were used. The animals were separated in two groups (G1 and G2). In G1, anesthesia was induced with propofol ( and maintained with sevoflurane (1.5 MAC). Thirty minutes after the begin of volatile anesthetic administration, the epinephrine infusion was initiated at a dose of At each 10 minutes the dose was increased in until For G2, the same methodology was used, except that sevoflurane was replaced by desflurane (1.5 MAC). At each epinephrine dose, the non-sinusal cardiac beats were counted and the occurrence of atrioventricular blockages was evaluated. The numerical data were submitted to Profile analysis and Kruskall-Wallis. The results allow to conclude that desflurane reduces in a more efficient way the arrhythmia produced by epinephrine and also the occurrence of atrioventricular blockages.

Keywords : arrhythmia; epinephrine; desflurane; sevoflurane.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License