Print version ISSN 0103-8478
GUIRRO, Erica Cristina Bueno do Prado; SOBRINHO, Guilherme Roberto; FERREIRA, Isabella Maria Marchesini and VALADAO, Carlos Augusto Araújo. Pre-emptive epidural injection of xylazine or amitraz, in horses: antinociceptive effect. Cienc. Rural [online]. 2009, vol.39, n.1, pp. 104-109. Epub Sep 03, 2008. ISSN 0103-8478. http://dx.doi.org/10.1590/S0103-84782008005000049.
Epidural administration of α2 agonists promotes antinociceptive effect and amitraz acts on α2 receptors. Antinociceptivo effect caused by pre-emptive epidural injection of 0.17mg kg-1 xylazine (GX) or 0.1mg kg-1 amitraz diluted in lipidic emulsion (GA) were evaluated, in 12 horses submitted by incisional model of inflammatory pain and evaluated about nociceptive threshold by mechanical stimulus (NTMS), by von Frey filaments. Xylazine produced maintenance of NTMS for 4 hours, while amitraz diluted in lipidic solution maintained NTMS for 24 hours.
Keywords : amitraz; analgesia; epidural; horses; nociception; xylazine.