Efficacy of meloxicam, administered by different routes was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval among them. At M0 and M1, 0.2mL of aqueous humor was collected and total protein and prostaglandin E2 (PGE2) quantitation was determined. Four groups were formed (n=5), which received meloxicam at the end of M0. by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII was performed. Results were evaluated statistically (P≤0.05). In all groups, protein and PGE2 values enhanced significantly in M1. Protein and PGE2 values did not change significantly between groups at M1. Inflammatory exudate of acute character and mild hemorrhage were seen at histopathology, after meloxicam administration. Meloxicam were unable to inhibit PGE2 synthesis and the protein influx to the anterior chamber by any of the tested routes.
uveitis; meloxicam; total protein; prostaglandin E2; dogs
