On-line version ISSN 1678-4596
MONTEIRO, Betânia Souza; ARGOLO NETO, Napoleão Martins and DEL CARLO, Ricardo Junqueira. Mesenchymal stem cell. Cienc. Rural [online]. 2010, vol.40, n.1, pp.238-245. ISSN 1678-4596. http://dx.doi.org/10.1590/S0103-84782010000100040.
Of all the stem cells studied so far, the mesenchymal stem cells (MSC) stand out for their high plasticity and capacity of generating mesodermal and non-mesodermal tissues. In addition, immunomodulatory and immunosuppressive features that expand possibilities for therapeutic use are present in these cells. A variety of pro and anti-inflammatory cytokines and growth factors are secrete for MSC and provide a modulation of inflammatory response, re-establishment of vascular supply and adequate repair of the tissue, contributing to tissue homeostasis under physiologic conditions. Therefore, they can induce secretion of soluble factors that stimulate their differentiation by other cells present at the niche's tissue, promoting the repair process. Cell therapy using MSC is a promises therapeutic alternative, but understanding the biology of these cells is still under construction. The aim of the article is to conduct a short review of these undifferentiated mesenchymal cells.
Keywords : cell therapy; immunological properties; growth factors; cytokines; tissue repair.