SciELO - Scientific Electronic Library Online

 
vol.47 número7Hidratação enteral em bezerros neonatos e características das soluções eletrolíticas disponíveis comercialmente no BrasilLuxação caudoventral de quadril em um mini-pig índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Ciência Rural

versão On-line ISSN 1678-4596

Resumo

ALVES, Endrigo Gabellini Leonel et al. Osteoprogenitor cells can enhance early bone formation in critical bone defects in dogs. Cienc. Rural [online]. 2017, vol.47, n.7, e20151109.  Epub 12-Jun-2017. ISSN 1678-4596.  http://dx.doi.org/10.1590/0103-8478cr20151109.

The aim of this study was to evaluate the effect of osteoprogenitor cells derived from mesenchymal stem cells from adipose tissue (OC-AD-MSCs), and differentiated into osteoblasts, in the treatment of critical bone defects in dogs. Adipose tissue derived mesenchymal stem cells (AD-MSCs) were subjected to osteogenic differentiation for 21 days and used in the treatment of bone defects in dogs radius. Either three experimental groups were bone defects treated with OC-AD-MSCs (OC), defects filled with autogenous bone (Control- C +), or empty defects (Control- C -). Bone regeneration was assessed by radiology, densitometry, and histomorphometry. The area of new bone formation was higher in the OC group compared to the control group (C-) on postoperative day 15. Defects treated with OC-AD-MSCs showed greater neovascularization than the other two groups at 90 days. We concluded that treatment with OC-AD-MSCs increased the area of new bone formation 15 days after surgery; however, it didn’t complete the bone union in critical bone defects in the radius of dogs at 90 days.

Palavras-chave : bone regeneration; orthopedics; cellular therapy; fracture non-union.

        · resumo em Português     · texto em Inglês     · Inglês ( pdf )