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Ciência Rural

versão impressa ISSN 0103-8478versão On-line ISSN 1678-4596

Resumo

OLIVEIRA, Letícia Batelli de et al. Wobbly syndrome in an Africa pygmy hedgehog (Atelerix albiventris): neuropathological and immunohistochemical studies. Cienc. Rural [online]. 2019, vol.49, n.1, e20180742.  Epub 31-Jan-2019. ISSN 0103-8478.  http://dx.doi.org/10.1590/0103-8478cr20180742.

A three-year-old female African pygmy hedgehog (Atelerix albiventris), born and domiciled in Brazil, presented apathy, prostration, and difficulty to stay standing. Its parents were siblings but did not present clinical signs related to this condition. As its clinical condition worsened, the animal was euthanized and referred for necropsy. No gross lesions were found in the central nervous system (CNS). Histologically, there was vacuolation with axonal degeneration in the white matter of the CNS and in peripheral nervous tissue. The Kluver-Barrera (KB) stain confirmed demyelination in vacuolated areas. Immunohistochemistry using several neural markers confirmed astrocytosis and microgliosis associated with vacuolated areas. In addition, there was a mild decrease in the immuno intensity of myelin proteolipid protein (PLP) in these areas. These results suggest a genetic origin of the present demyelination, which resulted in the wobbly syndrome described in this report.

Palavras-chave : central nervous system; degenerative disease; myelopathy; vacuolation; histopathology.

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