Feng K et al1414. Feng K, Yun YX, Wang XF, Yang GD, Zheng YJ, Lin CM, et al. [Analysis of CT features of 15 Children with 2019 novel coronavirus infection]. Zhonghua ErKe Za Zhi. [Internet]. 2020 [cited 2020 Apr 14];58(0):e007. [Article in Chinese]. Available from: https://dx.doi.org/10.3760/cma.j.issn.0578-1310.2020.0007 https://dx.doi.org/10.3760/cma.j.issn.05...
. 2020 China Medicine |
To analyze the characteristics of the site and shape of pulmonary lesions in CT scan of children with new coronavirus. |
15 children (4 to 14 years old) |
Non-randomized clinical study |
The lesions were located mainly under the pleura and showed irregular subpleural shadows or single nodular frosted glass shadows and halo signs. |
III |
Li W et al1515. Li W, Cui H, Li K, Fang Y, Li S. Chest computed tomography in children with COVID-19 respiratory infection. Pediatr Radiol. [Internet] 2020 [cited 2020 Apr 14];50(6):796-9. Available from: https://dx.doi.org/ 10.1007/s00247-020-04656-7 https://dx.doi.org/ 10.1007/s00247-020-0...
2020 China Medicine |
To describe thoracic CT scan findings in children with COVID-19. |
5 children (10 months to 6 years) |
Retrospective study |
Two children showed no signs of abnormality on thoracic Ct. Three showed characteristic radiological abnormality. |
IV |
Wang D et al1616. Wang D, Ju XL, Xie F, Lu Y, Li FY, Huang HH, et al. Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China. Zhonghua ErKe Za Zhi. [Internet]. 2020 [cited 2020 Apr 14];58(4):E011. Available from: https://dx.doi.org/10.3760/cma.j.cn112140-20200225-00138. https://dx.doi.org/10.3760/cma.j.cn11214...
2020 China Medicine |
To analyze the clinical characteristics of coronavirus-infected children. |
31 children (1 month to 7 years old) |
Retrospective cohort study |
Four cases were asymptomatic. Twenty cases had fever, fourteen had cough, three had fatigue, and three had diarrhea. |
IV |
Zheng F et al1717. Zheng F, Liao C, Fan Q-H, Chen H-B, Zhao X-G, Xie Z-G, et al. Clinical characteristics of children with Coronavirus disease 2019 in Hubei, China. Curr Med Sci. [Internet]. 2020 [cited 2020 Apr 14];40(2):275-80. Available from: https://dx.doi.org/ 10.1007/s11596-020-2172-6 https://dx.doi.org/ 10.1007/s11596-020-2...
2020 China Medicine |
To describe the clinical characteristics of pediatric cases infected with COVID-19. |
25 children (2 to 9 years old) |
Cross-sectional multicenter cohort study |
Children under 3 years old accounted for the majority of critical cases. |
IV |
Sun D et al1818. Sun D, Li H, Lu X-X, Xiao H, Ren J, Zhang F-R, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. [Internet] 2020 [cited 2020 Apr 14];19;1-9. Available from: https://dx.doi.org/10.1007/s12519-020-00354-4 https://dx.doi.org/10.1007/s12519-020-00...
2020 China Medicine |
To describe the clinical characteristics of severe pediatric patients with COVID-19. |
8 children (2 months to 15 years old) |
Retrospective cohort study |
The most common symptoms were tachypnea, fever, cough, expectoration, and nausea/vomiting. |
IV |
Lu X et al1919. Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in children. N Engl J Med. [Internet] 2020 [cited 2020 May 01];382:17. Available from: https://www.nejm.org/doi/pdf/10.1056/nejmc2005073?articleTools=true https://www.nejm.org/doi/pdf/10.1056/nej...
2020 China Medicine |
To assess the clinical characteristics of children infected with COVID-19. |
171 children (1 day to 14 years old) |
Observational study |
Fever was present in most children. Other common signs and symptoms include cough and erythema. |
IV |
Liu W et al 2020. Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of Covid-19 in children in early January 2020 in Wuhan, China. N Engl J Med. [Internet]. 2020 [cited 2020 Apr 11];382(14):1370-1 Available from: https://dx.doi.org/ 10.1056/NEJMc2003717 https://dx.doi.org/ 10.1056/NEJMc2003717...
2020 China Medicine |
To observe the clinical characteristics of COVID-19 in hospitalized children. |
366 children (1 to 6 years old) |
Retrospective study |
All had high fever (>39°C). Only 1 required hospitalization in a pediatric intensive care unit. |
III |
Xu Y et al2121. Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. [Internet]. 2020 [cited 2020 May 01];26(4):502-5. Available from: https://dx.doi.org/10.1038/s41591-020-0817-4 https://dx.doi.org/10.1038/s41591-020-08...
2020 China Medicine |
To assess the clinical characteristics of children infected with COVID-19. |
10 children (2 months to 15 years old) |
Prospective observational |
Seven had fever on admission. Other symptoms were cough (5), sore throat (4), nasal congestion and rhinorrhea (2), and diarrhea (3). One was asymptomatic. |
III |
Li Y et al2222. Li Y, Cao J, Zhang X, Liu G, Wu X, Wu B, et al. Imaging characteristics of COVID-19 pneumonia in preschool children: a retrospective study. BMC Pediatrics. [Internet]. 2020 [cited 2020 June 11];20(1):227. Available from: https://dx.doi.org/10.1186/s12887-020-02140-7 https://dx.doi.org/10.1186/s12887-020-02...
2020 China Medicine |
To investigate the thoracic imaging characteristics of COVID-19. |
8 children (1 to 5 years old) |
Retrospective study |
COVID-19 thoracic CT scan findings in preschool children may be atypical and varied. |
IV |
Li H et al2323. Li H, Chen K, Liu M, Xu H, Xu Q. The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia. J Infect [Internet]. 2020 [cited 2020 June 11];81(2020):115-20. Available from: https://dx.doi.org/10.1016/j.jinf.2020.04.001 https://dx.doi.org/10.1016/j.jinf.2020.0...
2020 China Medicine |
To investigate c-reactive protein, procalcitonin, serum creatinine, alanine aminotransferase, lymphocyte subsets, and cytokines. |
40 children with pneumonia 2019-nCoV (16 days to 14 years old) and 16 due to respiratory syncytial virus (RSV) (2 to 5 years old) |
Prospective descriptive study |
All tests showed higher rates in children with RSV pneumonia, except for one child with COVID -19 who had much higher Interleukin-10 levels and was the only one with severe pneumonia. |
IV |
Xia W et al2424. Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatric Pulmonology. [Internet]. 2020 [cited 2020 June 11];55(5):1169-74. Available from: https://dx.doi.org/10.1002/ppul.24718 https://dx.doi.org/10.1002/ppul.24718...
2020 China Medicine |
To discuss the clinical characteristics in pediatric patients with COVID-19. |
20 children (16 days to 14 years old) |
Retrospective study |
Clinical characteristics included fever (12), cough (13), diarrhea (3), nasal secretion (3), sore throat (1), vomiting (2), tachypnea (2), and fatigue (1). |
IV |
Lu Y et al2525. Lu Y, Wen H, Rong D, Zhou Z, Liu H. Clinical characteristics and radiological features of children infected with the 2019 novel coronavirus. Clin Radiol [Internet]. 2020 [cited 2020 June 11];75(2020):520-25. Available from: https://dx.doi.org/10.1016/j.crad.2020.04.010 https://dx.doi.org/10.1016/j.crad.2020.0...
2020 China Medicine |
To identify the common findings of COVID-19 in children. |
9 children (2 months to 15 years old) |
Retrospective study |
Four children had only fever, two fever and cough, one had cough and a nasal obstruction and rhinorrhea. One was asymptomatic. |
IV |
Soltani et al2626. Soltani J, Sedighi I, Shalchi Z, Sami G, Moradveisi B, Nahidi S. Pediatric coronavirus disease 2019 (COVID-19): An insight from west of Iran. North Clin Istanb. [Internet] 2020[cited 2020 June 11];7(3):284-91. Available from: https://dx.doi.org/10.14744/nci.2020.90277 https://dx.doi.org/10.14744/nci.2020.902...
2020 Iran Medicine |
To study the clinical characteristics of pediatric patients infected with COVID-19. |
30 children (1 day to 14 years old) |
Prospective descriptive study |
The most common symptoms were tachypnea, fever, cough, and dyspnea. None of them presented runny nose. |
IV |
Ma et al2727. Ma H, Hu J, Tian J, Zhou X, Li H, Laws MT, et al. A single-center, retrospective study of COVID-19 features in children: a descriptive investigation. BMC Medicine. [Internet]. 2020 [cited 2020 June 11];18(1):123. Available from: https://dx.doi.org/10.1186/s12916-020-01596-9 https://dx.doi.org/10.1186/s12916-020-01...
2020 China and USA Medicine |
To report relevant findings of patients positive for COVID-19. |
50 children (2 to 16 years old) |
Retrospective study |
There was no clear association between changes in CT lesions and clinical outcomes. |
III |