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Polímeros

versão impressa ISSN 0104-1428versão On-line ISSN 1678-5169

Resumo

REZENDE, Camila A.; LUCHESI, Carolina; BARBO, Maria de Lourdes P.  e  DUEK, Eliana A. R.. Poly (lactide-co-glycolide) membranes as skin repair: in vitro and in vivo degradation. Polímeros [online]. 2005, vol.15, n.3, pp.232-238. ISSN 1678-5169.  http://dx.doi.org/10.1590/S0104-14282005000300015.

Poly (lactide-co-glycolide) is a polymer with bioabsorption and biodegradation properties. The physical and chemical properties of this polymer have been studied in order to modulate its susceptibility to degradation and its interaction with cells and biological fluids, aiming at medical and dental applications. In this work, membranes of poly (lactide-co-glycolide) with and without plasticizer were prepared by solvent evaporation and characterized by in vitro and in vivo experiments. In vitro studies showed that the glass transition temperature decreased due to the addition of plasticizer and, consequently, their flexibility increased. During degradation, crystalline areas and porous appear. In vivo studies showed that the polymer degraded rapidly without causing inflammation and protected areas that were exposed to external agents. Furthermore, membranes improved wound healing time, indicating that they can be potentially used in skin repair.

Palavras-chave : Poly (lactide-co-glycolide); in vivo degradation; in vitro degradation; cicatrisation; membrane.

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