SciELO - Scientific Electronic Library Online

 
vol.22 número1Preparação de nanopartículas poliméricas a partir da polimerização de monômeros: parte I índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Polímeros

versão impressa ISSN 0104-1428

Resumo

SOUTO, Eliana B.; SEVERINO, Patrícia  e  SANTANA, Maria Helena A.. Preparation of polymeric nanoparticles from pre-formed polymers: part II. Polímeros [online]. 2012, vol.22, n.1, pp.101-106.  Epub 27-Jan-2012. ISSN 0104-1428.  http://dx.doi.org/10.1590/S0104-14282012005000005.

Polymeric nanoparticles have been produced by pre-formed polymers using aliphatic polyesters, which have been widely used to incorporate lipophilic drugs. The production of nanoparticles (nanospheres and nanocapsules) by pre-formed polymers can be performed by emulsification-solvent evaporation, solvent replacement, salting out or by emulsification-solvent diffusion. These methods are reviewed and discussed in this article, highlighting the technological parameters that influence the physicochemical characteristics of nanoparticles, such as the solubility of drug, the volume and pH of polymerization, the molecular weight and monomer concentration and the nature and concentration of the surfactant.

Palavras-chave : Pre-formed polymers; emulsification-solvent evaporation; solvent replacement; salting out or by solvent emulsification-diffusion.

        · resumo em Português     · texto em Português     · Português ( pdf epdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons