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Polímeros

versão impressa ISSN 0104-1428versão On-line ISSN 1678-5169

Resumo

OLIVEIRA, Edilene Gadelha de et al. Evaluation of Guar Gum in the development of theophylline controlled-release matrix tablets. Polímeros [online]. 2015, vol.25, n.spe, pp.54-58.  Epub 04-Dez-2015. ISSN 1678-5169.  https://doi.org/10.1590/0104-1428.1756.

Guar gum (GG) has been widely used in drug delivery systems due to its low cost and nontoxicity. Theophylline controlled release tablets were prepared by directly compressed method using two polymers such as HPMC K 100M (hydrophilic polymer) and Guar Gum (natural polymer), isolated or in mixture (GG:HPMC 3:1 and GG:HPMC 1:3). The formulated tablets were evaluated for: weight variation, diameter, height, hardness and friability. All the parameters were within the acceptable limits. The swelling test was performed in distilled water for 4 hours, it was determined by the difference in weight of the dry and swollen tablet. The dissolution test was performed in distilled water (900 mL, 37 ± 0.5ºC, 50 rpm, apparatus II) for 8 hours. The results showed that guar gum alone could not control the theophylline release effectively for 8 hours. Matrix tablet prepared from GG: HPMC (3:1) is a better formulation for the sustained released matrix tablets of theophylline.

Palavras-chave : Guar Gum; theophylline; tablets; controlled release.

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