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Polímeros

versão impressa ISSN 0104-1428versão On-line ISSN 1678-5169

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QUINTERO, Cirley; VERA, Ricardo  e  PEREZ, Leon Dario. α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties. Polímeros [online]. 2016, vol.26, n.4, pp.304-312.  Epub 08-Dez-2016. ISSN 0104-1428.  http://dx.doi.org/10.1590/0104-1428.2324.

α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core – shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.

Palavras-chave : α-tocopherol; polycaprolactone; thermosensitive nanoparticles; triblock copolymer.

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