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Revista da Associação Médica Brasileira

Print version ISSN 0104-4230On-line version ISSN 1806-9282


FEITOSA, Francisco Edson de Lucena et al. New formulation of sublingual misoprostol (25mcg) for induction of labor. Rev. Assoc. Med. Bras. [online]. 2006, vol.52, n.4, pp.251-255. ISSN 0104-4230.

OBJECTIVES: To determine effectiveness and safety of sublingual misoprostol in tablets of 25mcg, given every 6 hours for induction of labor in high-risk pregnant women hospitalized in two teaching hospitals in the Northeast of Brazil. METHODS: An open, non-randomized clinical trial was conducted, including 40 women with high-risk pregnancies hospitalized at "Maternidade-Escola Assis Chateaubriand" and "Instituto Materno-Infantil de Pernambuco". All of them had gestational age > 37 weeks, alive fetus with good vitality and Bishop scores < 7. A tablet of 25mcg of misoprostol was administered every 6 hours, up to a maximum of 4, until active labor. Statistical analysis was performed using the public domain software Epi-Info 3.2.2. RESULTS: Active labor occurred in 100% of cases after misoprostol administration. The mean (±SD) induction-to-labor interval was 4.8±3.8 hours. Interval from induction-to-delivery varied from 8 to 31 hours with 95% of the deliveries occurring in the first 24 hours with 75% of vaginal deliveries. The frequency of tachysystole was 12.5%. The women did not present relevant side effects neither were there any neonatal complications. CONCLUSIONS: The sublingual tablet of misoprostol of 25mcg was shown to be effective for induction of labor in high-risk pregnant women. The efficacy and acceptability of this new route should be compared to vaginal administration of misoprostol in future prospective randomized clinical trials.

Keywords : Misoprostol; Labor induction; Prostaglandins; Labor; Sublingual.

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