SciELO - Scientific Electronic Library Online

 
vol.56 issue2How to make consent forms easier to read? author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista da Associação Médica Brasileira

Print version ISSN 0104-4230

Abstract

SALGADO, Fabiana Xavier Cartaxo et al. Albumin and drug therapy in the prognosis of hospitalized elderly. Rev. Assoc. Med. Bras. [online]. 2010, vol.56, n.2, pp.145-150. ISSN 0104-4230.  https://doi.org/10.1590/S0104-42302010000200010.

OBJECTIVE: This study aimed to investigate the relationship between serum albumin levels, drugs used, length of hospitalization and number of diseases with the prognosis of hospitalized elderly. METHODS: A descriptive cross-sectional and retrospective study was carried out using a review of medical charts. Variables collected were disease motivating admission, albumin, drugs used and their affinity for albumin and length of stay in an elderly population of a Brazilian public hospital. We used multiple regression to assess whether age, length of stay, medication with or without affinity to albumin and number of drugs motivating admission were causes of death. The relation between dependent and independent variables was analyzed by two-way ANOVA. RESULTS: The sample consisted of 277 elderly, 151 with hypoalbuminemia and those using an average of 6.6 ± 3.80 different prescription drugs most of which had affinity for albumin (4.96 ± 2.64). Results showed that the number of drugs with affinity for albumin and hospital stay were predictors of death (r = 0.47, R2 = 0.224), (F(8.170) = 6.13; p=0.001). The relation between dependent and independent variables resulted in the mathematical equation: (death= 0.545 - 0.374 (albumin) - 0.195 (days of hospitalization) + 0.175 (number of drugs with affinity for albumin)). CONCLUSION: The mathematical equation obtained by this study demonstrated that albumin and days of hospitalization were inversely correlated with death and directly correlated with the number of drugs bound to albumin.

Keywords : Frail elderly; Hypoalbuminemia; Prescription drugs.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License