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Revista da Associação Médica Brasileira
Print version ISSN 0104-4230
CHINEM, Valquíria Pessoa and MIOT, Hélio Amante. Prevalence of actinic skin lesions in patients with basal cell carcinoma of the head: a case-control study. Rev. Assoc. Med. Bras. [online]. 2012, vol.58, n.2, pp.188-196. ISSN 0104-4230. http://dx.doi.org/10.1590/S0104-42302012000200014.
OBJECTIVE: To evaluate the prevalence of actinic skin lesions in patients with basal cell carcinoma of the head. METHODS: A case-control study was carried out. Cases were patients with primary, solid basal cell carcinoma of the head, less than two centimeters in diameter; and as controls, patients with other dermatoses. Constitutional and behavioral variables were analyzed, as well as actinic lesions. RESULTS: One hundred twenty cases and 360 controls were evaluated. Facial milia (OR = 2.3), leukoderma punctata of the upper limbs (OR = 2.9), and cutis rhomboidalis nuchae (OR = 1.8) were associated with neoplasms regardless of other variables, suggesting a risk phenotype. There was also association with light hair and eye color phenotypes, family genetics, and cumulative sun exposure. Sunburn, smoking, and alcoholism were not identified as risk factors. The use of sunscreens showed no evidence of protection; however, the control group consisted of dermatology patients who are often prescribed sunscreens. CONCLUSION: Actinic lesions were more prevalent in patients with solid basal cell carcinoma of the head than in controls, especially milia, cutis rhomboidalis nuchae, and leukoderma punctata, regardless of other known risk factors.
Keywords : Head and neck neoplasias; basal cell carcinoma; epidemiology; case-control studies; UV rays; risk factors.