Revista da Associação Médica Brasileira
versión impresa ISSN 0104-4230
BARBOSA, Eduardo Buzolin et al. Proteomics: methodologies and applications to the study of human diseases. Rev. Assoc. Med. Bras. [online]. 2012, vol.58, n.3, pp. 366-375. ISSN 0104-4230. http://dx.doi.org/10.1590/S0104-42302012000300019.
Proteomic approach has allowed large-scale studies of protein expression in different tissues and body fluids in discrete conditions and/or time points. Recent advances of methodologies in this field have opened new opportunities to obtain relevant information on normal and abnormal processes occurring in the human body. In the current report, the main proteomics techniques and their application to human disease study are reviewed.
Palabras llave : proteomics; neoplasms; polyacrylamide gel electrophoresis; mass spectrometry; diseases.