Miyaoka, 20033737 Miyaoka T, Yasukawa R, Tsubouchi K, Miura S, Shimizu Y, Sukegawa T, et al. Successful treatment of nocturnal eating/drinking syndrome with selective serotonin reuptake inhibitors. Int Clin Psychopharmacol. 2003; 18(3):175-7.
|
Case series |
Paroxetine (3 cases); fluvoxamine (1 case) |
4 patients with NES |
2 weeks |
Effective control of episodes of nocturnal eating after 2-3 weeks of treatment |
Winkelman, 20033535 Winkelman JW. Treatment of nocturnal eating syndrome and sleep-related eating disorder with topiramate. Sleep Med. 2003; 4(3):243-6.
|
Case series |
Topiramate |
2 patients with NES |
N/I |
Improved night eating, weight loss; the symptoms of NES returned one month after the end of treatment |
Tucker, 20043636 Tucker P, Masters B, Nawar O. Topiramate in the treatment of comorbid night eating syndrome and PTSD: a case study. Eat Disord. 2004; 12(1):75-8.
|
Case report |
Topiramate |
1 female aged 40 years |
9 months |
Improvement of symptoms of NES, sleepiness; weight loss |
O’Reardon, 20043838 O'Reardon JP, Stunkard AJ, Allison KC. Clinical trial of sertraline in the treatment of night eating syndrome. Int J Eat Disord. 2004; 35(1):16-26.
|
Open clinical trial |
Sertraline |
17 participants with NES (12 women) |
12 weeks |
Reduction in the number of awakenings; improvement in night eating |
O’Reardon, 20064848 Halford JC, Boyland EJ, Lawton CL, Blundell JE, Harrold JA. Serotonergic anti-obesity agents: past experience and future prospects. Drugs. 2011; 71(17):2247-55.
|
Double-blind, randomized, placebo-controlled trial |
Sertraline |
34 participants with NES (sertraline, n=17; placebo, n=17) |
8 weeks |
Improvement in symptoms of NES and in quality of life; weight loss |
Stunkard, 20064949 Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med. 2015; 21(2):166-72.
|
Open clinical trial |
Sertraline |
50 participants with NES |
Not informed |
Improvement in nocturnal hyperphagia, nocturnal awakenings with food intake, and depressive symptoms |
Cooper-Kazaz, 20125252 Crow S. Treatment of binge eating disorder. Curr Treat Options Psychiatry. 2014; 1(4):307-14.
|
Case report |
Topiramate |
1 female aged 54 years with NES and depression |
3 months |
Improvement in symptoms of NES, sleep quality and self-esteem |
Vander Wal, 20125050 Sebaaly JC, Cox S, Hughes CM, Kennedy MLH, Garris SS. Use of fluoxetine in anorexia nervosa before and after weight restoration. Ann Pharmacother. 2013; 47(9):1201-5.
|
Controlled randomized clinical trial |
Escitalopram |
40 participants with NES (escitalopram, n=20; placebo, n=20) |
6 weeks |
Improvement in symptoms of NES and weight loss did not differ between the groups |
Allison, 20135151 Flament MF, Bissada H, Spettigue W. Evidence-based pharmacotherapy of eating disorders. Int J Neuropsychopharmacol. 2012; 15(2):189-207.
|
Open clinical trial |
Escitalopram |
31 patients with NES (21 women) |
12 weeks |
Improvement in NES and depressive symptoms |
Milano, 20135555 Vander Wal JS, Gang CH, Griffing GT, Gadde KM. Escitalopram for treatment of night eating syndrome: a 12-week, randomized, placebo-controlled trial. J Clin Psychopharmacol. 2012; 32(3):341-5.
|
Case series |
Agomelatine |
5 patients with NES (3 women) |
10 weeks |
Improvement in symptoms of NES and depression; weight loss |
Milano, 20135454 Stunkard AJ, Allison KC, Lundgren JD, Martino NS, Heo M, Etemad B, et al. A paradigm for facilitating pharmacotherapy at a distance: sertraline treatment of the night eating syndrome. J Clin Psychiatry. 2006; 67(10):1568-72.
|
Case report |
Agomelatine |
1 female aged 39 years with NES and depression |
3 months |
Improvement in mood and symptoms of NES; weight loss |