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Revista da Associação Médica Brasileira

Print version ISSN 0104-4230On-line version ISSN 1806-9282

Abstract

CAMARGO, Celeste R. de et al. Uremic neuropathy: an overview of the current literature. Rev. Assoc. Med. Bras. [online]. 2019, vol.65, n.2, pp.281-286. ISSN 0104-4230.  https://doi.org/10.1590/1806-9282.65.2.281.

INTRODUCTION:

Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate.

Objectives:

This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment.

Methods:

This is a literature review of articles published on PubMed over the last 10 years using “Uremic Neuropathy” as “Title/Abstract”.

Results:

A total of nine articles that met the inclusion criteria were included. UN is a distal symmetric sensorimotor polyneuropathy that occurs due to the accumulation of uremic toxins associated with an oxidative stress-related free radical activity. Hyperkalemia is thought to play an important role in its pathophysiology. Diagnosis depends on nerve conduction studies, and treatment includes dialysis or renal transplant.

Conclusion:

Clinical presentations of UN are broad and non-specific; nonetheless, it is important to detect early changes in order to avoid its progression. The earlier UN is diagnosed and treated, the more successful are the clinical outcomes.

Keywords : Neural conduction; Dialysis; Kidney Transplantation; Peripheral Nervous System Diseases; Uremia/complications.

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