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Revista da Associação Médica Brasileira

Print version ISSN 0104-4230On-line version ISSN 1806-9282

Abstract

UINT, Luciana et al. Increased levels of plasma IL-1b and BDNF can predict resistant depression patients. Rev. Assoc. Med. Bras. [online]. 2019, vol.65, n.3, pp.361-369.  Epub Apr 11, 2019. ISSN 0104-4230.  https://doi.org/10.1590/1806-9282.65.3.361.

BACKGROUND:

There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result in Coronary Artery Disease occurrence.

OBJECTIVE:

This study aimed to compare the subclinical atherosclerosis markers, inflammatory profile, and BDNF production in Resistant Depression (RD) or Bipolar Affective Disorder (BAD) patients under conventional treatment.

METHODS:

The population evaluated was comprised of 34 RD, 43 BAD, and 41 controls. Subclinical atherosclerosis markers were evaluated using ultrasonography, tomography, and exercise stress test. Plasma concentrations of TNFα, IL-1β, IL-6, and BDNF were measured using Luminex100™. The usCRP concentration was measured using turbidimetric immunoassay. IL1B, IL6, and TNFA expression were determined using TaqMan®. For the statistical analysis, the significance level was established at p<0.05.

RESULTS:

Concerning subclinical atherosclerosis markers, only O2 consumption was reduced in the BAD group (p = 0.001). Although no differences were found in gene expression, BDNF and IL-1β plasma concentration was increased in the RD group (p = 0.002 and p = 0.005, respectively) even with an antidepressant treatment, which suggests that these drugs have no effect in IL-1β secretion and that the inflammasome may play a role in therapy response.

CONCLUSION:

Taken together, both BDNF and IL-1β plasma concentrations could be used to the early identification of RD patients.

Keywords : Bipolar Affective Disorder; Depression; Inflammation; Atherosclerosis; BDNF; IL-1β.

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