A meta-analysis on the association of genetic polymorphism of the angiotensin-converting enzyme and coronary artery disease in the chinese population

Zhang, Yongjun; Yang, Tao; Zhou, Wenjiao; Huang, Yuee

doi:10.1590/1806-9282.65.6.923

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Review Article • Rev. Assoc. Med. Bras. 65 (6) • June 2019 • https://doi.org/10.1590/1806-9282.65.6.923 copy

A meta-analysis on the association of genetic polymorphism of the angiotensin-converting enzyme and coronary artery disease in the chinese population

Authorship SCIMAGO INSTITUTIONS RANKINGS

SUMMARY

OBJECTIVE:

To investigate the association between genotype insertion or deletion polymorphism of the angiotensin-converting enzyme gene (ACE) and susceptibility to coronary artery disease (CAD) in Chinese Han population.

METHODS:

We conducted a comprehensive search for the OR value of contrast between the group of genotype insertion or deletion polymorphism of the ACE and the group of CAD as an effective index. A meta-analysis (Stata 12.0) was used to test the heterogeneity of the results, combine the values for effect, conduct sensitivity analysis, and basic evaluation.

RESULTS:

A total of 638 studies were found on the association between polymorphisms of the angiotensin-converting enzyme gene and CAD, of which 44 studies met the inclusion criteria. In total, our study included 5619 cases and 4865 controls. The heterogeneity test of each study (P < 0.001) was carried out using a random effect model. The OR value of DD/ID+II was 1.95, 95% confidence interval (95%CI) (1.66-2.29). The OR value of II/DI+DD was 0.63, 95%CI (0.55-0.72). The funnel figure is basically symmetrical and the results of the sensitivity analysis were stable.

CONCLUSION:

The DD genotype of the angiotensin converting enzyme gene may be a weaker risk factor for CAD in the Chinese Han population.

KEYWORDS:
Angiotensin-converting enzyme gene; Gene polymorphism; Coronary artery disease; Meta-Analysis

First author	Year	Region	CAD patients		non-CAD control		NOS score
First author	Year	(province/city)	Total	D frequency	Total	D frequency	NOS score
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[1] CORRESPONDING AUTHOR: Yuee Huang, No. 22, Wenchang West Road, Yijiang District, Wuhu City, Anhui Province – WuHu, China – 241002 E-mail: huangyewindow@163.com

Study group (N° of studies)	N° of patients with DD genotype/DI and II N° of patients		Combined OR(95%-CI)	N° of patients with II genotype/ DI and DD N° of patients		Combined OR(95%-CI)
Study group (N° of studies)	CAD cases	No CAD controls	Combined OR(95%-CI)	CAD cases	No CAD controls	Combined OR(95%-CI)
<100 cases (2)	23/68	11/69	2.303[0.772,6.870]	34/57	33/47	0.792[0.422,1.488]
100-200 cases (22)	581/1211	283/1298	2.311 [1.883, 2.836]	439/1353	593/988	0.499[0.406, 0.612]
≥200 case (20)	1002/2734	577/2627	1.680 [1.337, 2.111]	1222/2514	1276/1928	0.745[0.632, 0.879]
Test for heterogeneity	Q=7.54	P=0.023		Q=11.98	P=0.003
Combined OR (95%CI)	1.919	[1.510, 2.438]		0.659	[0.505, 0.860]
	Z=5.33	P<0.001		Z= 3.07	P=0.002