Girolamo Fracastoro wrote two works on syphilis: his famous poem, in which he gave a name to the disease, and a prose treatise. From the comparison of these works, in this paper we have identified the combination of several approaches as main characteristic of his description. On the one hand Fracastoro followed the classical medical explanation that emphasized the corruption of the air in order to explain the origins of the disease. On the other hand, when referring to the forms of contagion, he stated clearly that the disease is contracted by direct contact with an infected person. It is possible then to talk of the "invention" of syphilis by Fracastoro since he combined the information empirically collected, with the renaissance medical traditional perspective.
Girolamo Fracastoro (1478-1553); syphilis; contagion; air propagation