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Brazilian Journal of Chemical Engineering

Print version ISSN 0104-6632


GHOJAVAND, H.; BONAKDARPOUR, B.; HEYDARIAN, S. M.  and  HAMEDI, J.. The inter-relationship between inoculum concentration, morphology, rheology and erythromycin productivity in submerged cultivation of Saccharopolyspora erythraea. Braz. J. Chem. Eng. [online]. 2011, vol.28, n.4, pp.565-574. ISSN 0104-6632.

Submerged cultivation of Saccharopolyspora erythraea, at different initial spore concentrations, was carried out to study the inter-relationship between inoculum concentration, morphology, rheology and erythromycin production. Pellet morphology was dominant in runs at 103 and 104 spore/ml initial spore concentrations, whereas there was a significant presence of clump morphology in runs at initial spore concentrations of 105-107 spore/ml. The S. erythraea cultivation broths exhibited Newtonian rheology in runs at initial spore concentrations of 103 and 104 spore/ml, whereas at higher initial spore concentrations the rheological data could be fitted with the power law model. Runs in which clump morphology was predominant resulted in the highest erythromycin productivities. The findings of the present work suggest that the predominance of clump morphology, smaller sized clumps and, in the case of non-Newtonian S. erythraea cultivation broths, a decrease in viscosity enhance erythromycin production.

Keywords : Erythromycin; Saccharopolyspora erythraea; Morphology; Inoculum spore concentration.

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