Histiocytes are no longer recognized as singular cells. The term ‘histiocyte’ now refers to a heterogeneous group of cells with unique histologic morphology, but with singular functions and characteristics. Histiocytoses are a group of different diseases caused by proliferative histiocytes. Such diseases are rare and their study usually tends to be difficult. The objective of this paper is to simplify the study of these diseases under the novel paradigm of histiocyte heterogeneity.
Histiocytosis; non-Langerhans cell histiocytoses; histiocytes; macrophages
