Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
MARQUES, Silvio Alencar. Paracoccidioidomycosis: epidemiological, clinical and treatment up-date. An. Bras. Dermatol. [online]. 2003, vol.78, n.2, pp.135-146. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962003000200002.
The present report provides new data related to the epidemiology, clinical aspects and treatment of paracoccidioidomycosis. The epidemiological impact of the isolation of Paracoccidioides brasiliensis from the armadillo (Dasypus novemcinctus) in areas of Brazil and Columbia, the results from seroepidemiologic study in dogs and the first case of paracoccidioidomycosis-disease on a dog are presented. New insights related to the classical difficulties of isolation of the fungus from soil are correlated with epidemiological data. Clinical manifestation of the acute form of the disease as well as aspects of the neuroparacoccidioidomycosis, and aspects of the association of the disease with the HIV infection are considered. The role of serology and PCR in the diagnosis, as well as the possible advances in the treatment of paracoccidioidomycosis with the new triazole derivatives are discussed.
Keywords : diagnosis; epidemiology; paracoccidioidomycosis; therapeutics.