Abstract

BRITO, Maria de Fátima de Medeiros; SANT'ANNA, Iara Pessoa  and  FIGUEIROA, Fábia. Evaluation of the side effects of acitretin on children with ichthyosis: a one-year study. An. Bras. Dermatol. [online]. 2004, vol.79, n.3, pp. 283-288. ISSN 1806-4841.  http://dx.doi.org/10.1590/S0365-05962004000300003.

BACKGROUND: Systemic retinoids are one of the most important dermatological therapeutics recently discovered for treating disorders of keratinization, such as psoriasis, ichthyosis and acne OBJECTIVES: The objective of this study was to evaluate the impact of the use of these drugs on lipid metabolism, hepatic system and on bone. METHODS: Prospective study. Ten children with ichthyosis were evaluated during one year. Each was treated with a dose of 10 mg.day or approximately 0.5 mg.kg-1.day. This dosage was adjusted on the basis of clinical efficacy or tolerance and maintained for one year. RESULTS: All ten children presented improvement by the end of one year. There were no alterations in transaminases, serum lipids and only one child out of six evaluated for bone age presented alterations. CONCLUSION: The use of acitretin when administered at a correct dosage for a one-year period is secure and effective. The beneficial effect of the drug and its minimal toxicity shown in this study justify its use in children.

Keywords : acitretin; child; Ichthyosis, Lamellar.