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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
OLIVEIRA-NETO, Manoel P; MATTOS, Marise; CUZZI-MAYA, Tulia and PIRMEZ, Claude. Localized eosinophilic panniculitis following intramuscular injection of pentavalent antimonium for treatment of american tegumentary leishmaniasis. An. Bras. Dermatol. [online]. 2004, vol.79, n.4, pp. 389-390. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962004000400008.
Eosinophilic panniculitis may be induced by several triggering factors and this syndrome is described here following the intramuscular injection of antimonial compounds for treatment of American muco-cutaneous leishmaniasis. Three patients, treated with intramuscular injections of pentavalent antimony (Glucantime®) were studied through clinical examination, histopathology and immunologic methods. The three patients developed deep infiltrated plaques at the site of antimony injection. Histopathology disclosed a prominent inflammatory infiltrate of the subcutaneous fat with numerous eosinophils. Immunologic studies could not detect immunoglobulins or complement fractions in the lesions. The final diagnosis was eosinophilic panniculitis occurring as a side-effect of antimonial therapy. The pathogenesis was not clear and it is suggested that the disease could be induced by a physical factor such as pressure or an immunological reaction to antimony.
Keywords : antimony [adverse effects]; leishmaniasis, cutaneous [therapy]; panniculitis.