SciELO - Scientific Electronic Library Online

 
vol.79 issue6Identification of Candida species and antifungal susceptibility in vitro: a study on 100 patients with superficial candidiasisLaser and intense pulsed light: induction and treatment of allergic reactions related to tattoos author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596On-line version ISSN 1806-4841

Abstract

LIMA, Daniela A.; ROCHA, Daniela M.  and  MIRANDA, Mario F. R.. Gianotti-Crosti syndrome: clinical, laboratorial features, and serologic profiles of 10 cases from Belém, State of Para, Brazil. An. Bras. Dermatol. [online]. 2004, vol.79, n.6, pp.699-707. ISSN 0365-0596.  http://dx.doi.org/10.1590/S0365-05962004000600006.

BACKGROUND: Gianotti-Crosti syndrome (GCS) is a rare, self-limited disease characterized by a symmetrical erythematopapulous, acral-based eruption. In most cases a definite relationship with a viral infection can be established, especially when hepatitis B or Epstein-Barr viruses are involved. However, few case reports on associations between GCS and human herpesvirus 6 (HHV6) have been published to date. OBJECTIVE: To study clinical and laboratorial aspects as well as to investigate the role of viral pathogens in the etiology of GCS cases from Belem (PA), Brazil. PATIENTS AND METHODS: From August 1996 to December 2002, ten children with a clinical diagnosis of GCS were investigated through routine laboratory exams and serologically screened for several virus specific antibodies. A diagnosis of GCS was considered for cases that presented clinical aspects considered suggestive, together with one or more of the following criteria: elevated titers of hepatic enzymes, lymphocytosis, positive viral serology or history of a prior vaccination. RESULTS: Six out of 10 children (60%) showed evidence of HHV6 primary infection, as demonstrated through specific IgM-antibody positivity. CONCLUSION: Anti-HHV6-IgM antibody positivity in 6/10 patients suggests that the pathogen can play a role in the etiology of GCS. Consequently, the authors recommend that this virus is added to the routine serological tests when exanthematous processes are concerned, especially those with a morphology suggestive of GCS.

Keywords : acrodermatitis; hepatitis C antibodies; exanthema; herpesvirus 6, human.

        · abstract in Portuguese     · text in English | Portuguese     · English ( pdf epdf ) | Portuguese ( pdf epdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License