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Anais Brasileiros de Dermatologia
Print version ISSN 0365-0596
On-line version ISSN 1806-4841
LIMA, Daniela A.; ROCHA, Daniela M. and MIRANDA, Mario F. R.. Gianotti-Crosti syndrome: clinical, laboratorial features, and serologic profiles of 10 cases from Belém, State of Para, Brazil. An. Bras. Dermatol. [online]. 2004, vol.79, n.6, pp.699-707. ISSN 0365-0596. http://dx.doi.org/10.1590/S0365-05962004000600006.
BACKGROUND: Gianotti-Crosti syndrome (GCS) is a rare, self-limited disease characterized by a symmetrical erythematopapulous, acral-based eruption. In most cases a definite relationship with a viral infection can be established, especially when hepatitis B or Epstein-Barr viruses are involved. However, few case reports on associations between GCS and human herpesvirus 6 (HHV6) have been published to date. OBJECTIVE: To study clinical and laboratorial aspects as well as to investigate the role of viral pathogens in the etiology of GCS cases from Belem (PA), Brazil. PATIENTS AND METHODS: From August 1996 to December 2002, ten children with a clinical diagnosis of GCS were investigated through routine laboratory exams and serologically screened for several virus specific antibodies. A diagnosis of GCS was considered for cases that presented clinical aspects considered suggestive, together with one or more of the following criteria: elevated titers of hepatic enzymes, lymphocytosis, positive viral serology or history of a prior vaccination. RESULTS: Six out of 10 children (60%) showed evidence of HHV6 primary infection, as demonstrated through specific IgM-antibody positivity. CONCLUSION: Anti-HHV6-IgM antibody positivity in 6/10 patients suggests that the pathogen can play a role in the etiology of GCS. Consequently, the authors recommend that this virus is added to the routine serological tests when exanthematous processes are concerned, especially those with a morphology suggestive of GCS.
Keywords : acrodermatitis; hepatitis C antibodies; exanthema; herpesvirus 6, human.