Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
SILVA, Márcia de Matos; BOUZAS, Luis Fernando S. and FILGUEIRA, Absalom L.. Tegumentary manifestations of graft-versus-host disease in bone marrow transplantation recipients. An. Bras. Dermatol. [online]. 2005, vol.80, n.1, pp. 69-80. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962005000100010.
Graft-versus-host disease (GVHD) is a systemic disease that occurs in patients that receive immunocompetent lymphocytes. Pathophysiology involves an immunologic reaction between transplanted lymphocytes and tissues of the host, through an immune attack of donor T cells against recipient cells that differ from the donor's by histocompatibility antigens. It is a major complication of allogeneic hematopoietic stem cell transplantation. GVHD skin involvement is frequent and contributes to morbidity and mortality of bone marrow transplantation. Dermatologists have an important role on patient's evaluation, providing early diagnosis of GVHD disease and its complications, so as to follow-up these patients. In this review, we emphasize the skin manifestations of GVHD, taking into account our 14-year personal experience at Centro Nacional de Transplante de Medula Óssea/INCA/MS.
Keywords : Graft vs host disease; Bone marrow transplantation; Transplantation, homologous.