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Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596On-line version ISSN 1806-4841


WOLLINA, Uwe; WURBS, Claudia  and  SCHONLEBE, Jaqueline. Lymphomatoid papulosis: report of two cases. An. Bras. Dermatol. [online]. 2005, vol.80, n.2, pp.161-164. ISSN 0365-0596.

Lymphomatoid papulosis (LP) is a rare variant of cutaneous T-cell lymphomas with large CD30-positive intracutaneous T-cell infiltrate. There is a discrepancy between histology suggesting a highly malignant and aggressive disease and the chronic relapsing mostly self limiting course in most cases. We report two patients. A 64-year-old woman with a 10-year history of LP was treated with cream PUVA that was able to control the disease. The other case, a 42-year-old woman had an 18-year history of LP treated by PUVA and later by extracorporeal photochemotherapy (ECP). During ECP a rapid metastatic spread developed that could not be controlled by polychemotherapy. Eventually she died due to a central nervous system metastasis one year later.

Keywords : Photopheresis; Lymphoma, T-cell, cutaneous; Lymphomatoid papulosis; PUVA therapy.

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