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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
FERNANDES, Nurimar C. and ZUBATY, Vanessa M.. Cyclophosphamide pulse therapy for pemphigus: report of seven cases. An. Bras. Dermatol. [online]. 2005, vol.80, n.2, pp. 165-168. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962005000200007.
The efficacy of cyclophosphamide pulse therapy was evaluated in pemphigus vulgaris (2 males and 4 females aged 34 to 47 years) and in a 56-year-old male with pemphigus foliaceus. The inclusion criteria for pulse therapy were: prednisone failure, important side effects, recurrence of disease during the withdrawal and maintenance oral prednisone > 40 mg daily. In one case (5 pulses), the maintenance dose of prednisone was reduced to 10 mg; in another case (9 pulses), to 20 mg; in 2 cases (10 pulses), to 20 mg; in 1 case (9 pulses), to 30 mg; in 1 case (7 pulses), no prednisone was required; and in 1 case, the cyclophosphamide was interrupted due to leukopenia.
Keywords : Cyclophosphamide; Pemphigus; Pulse.