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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
SANTAMARIA, Jesus Rodriguez et al. Antiphospholipid syndrome. An. Bras. Dermatol. [online]. 2005, vol.80, n.3, pp.225-239. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962005000300002.
Antiphospholipid syndrome is an acquired multisystem disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified into 2 groups: primary and secondary. Secondary antiphospholipid syndrome is often associated with systemic lupus erythematosus and less frequently with infections, drugs and other diseases. Serologic markers are antiphospholipid antibodies, lupus anticoagulant and anticardiolipin. The primary diagnostic criteria include arterial thrombosis or venous thrombosis and recurrent fetal loss. About 41% of patients with lupus anticoagulant have skin lesions as the first sign of antiphospholipid syndrome. Cutaneous manifestations include livedo reticularis, cutaneous ulceration and livedo vasculitis. The mainstays of prophylaxis and treatment of thrombosis are anticoagulant and antiplatelet agents.
Keywords : Skin manifestations; Antiphospholipid syndrome; Thrombosis.