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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
WEBER, Magda Blessmann et al. Evaluating the relation between pruritus, serum IgE levels and severity of clinical manifestations in atopic dermatitis patients. An. Bras. Dermatol. [online]. 2005, vol.80, n.3, pp.245-248. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962005000300003.
BACKGROUND: Atopic dermatitis patients often have high serum immunoglubulin E (IgE) levels and pruritus is a major symptom of the disorder. OBJECTIVE: To describe the characteristics of pruritus in atopic dermatitis (AD) patients and to correlate severity of eczema with plasma IgE levels. METHODS: Patients with atopic dermatitis seen at the Dermatology Service of Hospital de Clínicas de Porto Alegre and at the Dermatology and Pediatrics Service of Universidade Luterana do Brasil filled out a questionnaire on AD symptoms and had their blood collected for serum IgE levels. Severity of dermatitis was assessed according to criteria adopted by Rajka et al. Data were analyzed by SPSS program. RESULTS: Eighty-nine patients completed the study. The mean age was 9.6 ± 9 years and 51% were female. The relation between frequency of pruritus and severity of dermatitis was significant (p=0.003). Forty-five percent of patients with mild atopic dermatitis presented pruritus every day, 90.9% of severe patients showed daily symptoms, and only 4.5% remained symptom-free for more than seven days. The median serum IgE level was 347 UI/ml. The median serum IgE levels for mild, moderate and severe cases was 279 UI/ml, 347 UI/ml and 952UI/ml, respectively (p=0.699). Females showed significantly lower serum IgE levels when compared to males (212 UI/ml vs. 2067 UI/ml, p=0.004). CONCLUSIONS: Although IgE levels were higher in severe patients, this study did not demonstrate a trend toward greater levels in patients with severe eczema as compared with mild eczema. Males have significantly higher serum IgE levels than females.
Keywords : Dermatitis; atopic; Immunoglobulin E; Pruritus.