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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
CALADO, Karla Lucena Sampaio et al. Seropositivity with anti-PGL-I of household and neighbours contacts of leprosy patients in an urban area. An. Bras. Dermatol. [online]. 2005, vol.80, suppl.3, pp.S301-S306. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962005001000007.
BACKGROUND: Actually many studies have been made to evaluate the predictive value of tests that identify patients infected by Mycobacterium leprae. Among then, the serology that determinates the presence o M. leprae specific antibody. OBJECTIVES: To know the infections tax among households and direct neighbours contacts, establish soropositivity relationship according to sex, household/ neighbour, age and classification of leprosy of the index case (paucibacillary x multibacillary). PATIENTS AND METHODS: seroepidemiological study covering all the household and neighbours of leprosy patients diagnosticated from 1998 to 2002, in the second district of Duque de Caxias, Rio de Janeiro, using fast ML-Flow. RESULTS: A total of 2.130 contacts were identified in 390 domiciles of leprosy patients. Of the 2130 contacts, 1866 were submmited to serology (12.4% lost). Seroprevalence was 15,7%(292/1866); 15.8% household and 15.6% neighbour. The relationship of seropositivity with sex and age (>15 >15 years old) did not shown any statistic difference. But it was seen among contacts of MB index cases ( 67,5%) 2 times higher than contacts of PB cases (32,5%). DISCUSSION / CONCLUSION: In highly endemic areas for leprosy, situated at peripheral metropoliten cities not only household contacts of the index case, but also people living in the close vicinity were more likely to harbour antibodies against M. leprae. Through measuring the serological status of contacts and using a broader definition for them, higher risk groups can be more specifically identified.
Keywords : Epidemiological surveillance; Leprosy; Serology.