Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
GONCALVES, Washington Luiz S. et al. Use of low intensity ultrasonic therapy in the reduction of gynecoid lipodystrofy: a safe therapy or transitory cardiovascular risk? A pre-clinical study. An. Bras. Dermatol. [online]. 2005, vol.80, suppl.3, pp. S352-S359. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962005001000015.
BACKGROUND: The ultrasound (US) diffusion as therapeutical methods, has corroborated the profile of security observed in the medicine practice, however, not always it has been based in systematic studies, suggesting measured caution and improvement in application on this technique. OBJECTIVES: To evaluate the potential risk of the use low intensity ultrasound (3MHz) in the gynecoid lipodystrofy (cellulite) treatment and in the cardiovascular system implications. METHODS: Female rats (Wistar) were divided in 02 groups: Control-Sham and Ultrasound Therapy (UST). After induced anesthesia with halotano, the rats had been submitted to UST pulse way, with power 1,0W/cm2 and 3 MHz frequency in the inguinal region (3cm2), during 03 min. per 10 days. At the treatment end, after anesthesia with Chloral 10% (0,4mL / 100g) a catheter made of PE-50 tubing connected to PE-10 tubing was implanted in the femoral artery, the blood pressure (BP) and hart rate (HR) was measured; the blood was collected for determination of lipids and glucose levels. To follow, hearts were isolated and perfused by Langendorff apparatus; was determined the baseline coronary perfused pressure (CPP) after 40 minutes and determined dose-response curve by adenosine. Data were analyzed by one-way ANOVA for independent sample, followed by the Tukey test for comparison of the means. Differences were considered significant when P<0.05 and values were reported as mean+SEM. RESULTS: We observed increase (P<0,01) in blood pressure in the UST (114+1) vs. in the control-sham (103+1)mmHg group. The serum glucose (97+2 vs. 133+6 mg/dL) and lipids profile showed significant differences in the LDL-C (10+1 vs. 14+1 mg/dL) HDL-C (59+1 vs. 54+1 mg/dL); triglyceride (33+2 vs. 82+6 mg/dL) in the control and UST groups, respectively. The baseline CPP was reduced (P<0,01) from 94+2 mmHg in the control-sham to 79+1 mmHg in the UST group. CONCLUSIONS: Immediately after use of ultrasound therapy, the hemodynamics parameters and serum lipids and glucose levels were modified and producing attenuation induced-vasodilatation by adenosine. Therefore, we can consider that the UST increases the cardiovascular risk in female rats.
Keywords : Cellulitis; Lipodystrofy; Ultrasonics.