Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
ROCHA JUNIOR, Adeir Moreira et al. Modulation of fibroblast proliferation and inflammatory response by low-intensity laser therapy in tissue repair process. An. Bras. Dermatol. [online]. 2006, vol.81, n.2, pp. 150-156. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962006000200006.
BACKGROUND: Several studies have been performed to understand the tissue repair process as well as the possible effects of laser therapy in wound healing. OBJECTIVES: To study the behavior of skin wounds induced in the dorsal region of Wistar rats (Rattus norvegicus), which were submitted to the low-intensity laser therapy at 3.8 J/cm2 dosage, 15mW potency, during 15 seconds. MATERIAL AND METHODS: The animals (n=12) were divided into two groups - control and laser-treated. The latter comprised three applications (immediately after surgery, 48 hours and 7 days after induction of surgical wounds). Ten days after surgery samples of the wounds were collected and submitted to histopathological and histomorphometric studies. RESULTS: Neovascularization, fibroblast proliferation and reduced inflammatory infiltrate in surgical wound submitted to laser therapy were demonstrated. CONCLUSION: Taken together, the results suggest that low-intensity laser therapy is an effective method to modulate tissue repair, thus significantly contributing to a faster and more organized healing process.
Keywords : Laser therapy; low-level; Rats; Wound healing.