SciELO - Scientific Electronic Library Online

 
vol.81 issue5Genetic analysis of p16 gene by PCR-SSCP technique and protein p16 expression in oral mucosa and skin melanomasCutaneous melanoma: population-based study in Goiania, Brazil, from 1988 to 2000 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Anais Brasileiros de Dermatologia

On-line version ISSN 1806-4841

Abstract

MESSINA, Maria Cristina de Lorenzo; VALENTE, Neusa Yuriko Sakai  and  CASTRO, Luiz Guilherme Martins. Is incisional biopsy helpful in the histopathological classification of basal cell carcinoma?. An. Bras. Dermatol. [online]. 2006, vol.81, n.5, pp. 443-448. ISSN 1806-4841.  http://dx.doi.org/10.1590/S0365-05962006000500006.

BACKGROUND: Basal cell carcinoma is a tumor with many histologic types, each one with different aggressiveness potential. The known correlation between histologic types found in preoperative biopsy samples and excisional specimens is not absolute. Correspondence rates vary from 42.7 to 80.0% in medical literature. OBJECTIVE: To evaluate the correlation between histologic types of basal cell carcinoma in preoperative biopsies and their respective excised surgical specimens. METHODS: A retrospective analysis of 70 primary basal cell carcinoma cases submitted to preoperative biopsies and excisional surgery. The histologic evaluation was performed according to standard practice determining both the predominant and secondary histologic types found in preoperative biopsy materials and surgically excised specimens. RESULTS: There was a 78.3% correlation rate between the predominant histologic type of the biopsy and the surgical specimen, and an 87% correspondence between the predominant histologic type and/or secondary histologic type of the biopsy and/or predominant histologic type of the surgical specimen. CONCLUSION: The preoperative biopsy is useful for predicting the predominant basal cell carcinoma histologic type of the surgical excisional specimen in most cases. Nevertheless, when only the predominant histologic type found in biopsy is described, there is a 21.7% failure rate in diagnosis. When both predominant histologic types and secondary histologic types found in the biopsy are described, diagnostic failure drops to 13%.

Keywords : Basal cell carcinoma; Biopsy; Histology; Surgery.

        · abstract in Portuguese     · text in English | Portuguese     · pdf in English | Portuguese