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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
MARQUES, Silvio Alencar et al. Pythium insidiosum: report of the first case of human infection in Brazil. An. Bras. Dermatol. [online]. 2006, vol.81, n.5, pp.483-485. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962006000500012.
Pythiosis is caused by an aquatic fungus-like organism, Pythium insidiosum, pathogenic to men and animals. A patient with a phagedenic ulcer on the leg is reported. Histopathological examination was suggestive of zygomycosis, response to antifungal drugs was poor and cure was obtained by means of wide surgical excision. Etiologic diagnosis was confirmed by molecular amplification and DNA sequencing of colonies isolated in Sabouraud agar. After BLAST analysis, the sequence showed 100% identity with those of P. insidiosum deposited on the GenBank.
Keywords : Brazil; Humans; Pythium; Skin ulcer.